Hypoxia induces re-entry of committed cells into pluripotency
نویسندگان
چکیده
منابع مشابه
Extract of mouse embryonic stem cells induces the expression of pluripotency genes in human adipose tissue-derived stem cells
Objective(s): In some previous studies, the extract of embryonic carcinoma cells (ECCs) and embryonic stem cells (ESCs) have been used to reprogram somatic cells to more dedifferentiated state. The aim of this study was to investigate the effect of mouse ESCs extract on the expression of some pluripotency markers in human adipose tissue-derived stem cells (ADSCs). Materials and Methods: Human A...
متن کاملHypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells.
We have investigated the changes of cytosolic [Ca2+] and the secretory activity in single glomus cells dispersed from rabbit carotid bodies during exposure to solutions with variable O2 tension (Po2). In normoxic conditions (Po2 = 145 mmHg; 1 mmHg = 133 Pa), intracellular [Ca2+] was 58 +/- 29 nM, and switching to low Po2 (between 10 and 60 mmHg) led to a reversible increase of [Ca2+] up to 800 ...
متن کاملPluripotency re-centered around Esrrb.
The orphan nuclear receptor estrogen-related receptor b (Esrrb) is a vital component of the core pluripotency network in embryonic stem cells (ESCs). However, its function is not clear and the identity of potential upstream regulators has remained elusive. Three elegant reports (Festuccia et al, 2012; Martello et al, 2012; Percharde et al, 2012) have now elucidated the role of Esrrb in ESC self...
متن کاملTapping into the glial reservoir: cells committed to remaining uncommitted
The development and maturation of the oligodendrocyte requires a series of highly orchestrated events that coordinate the proliferation and differentiation of the oligodendrocyte precursor cell (OPC) as well as the spatiotemporal regulation of myelination. In recent years, widespread interest has been devoted to the therapeutic potential of adult OPCs scattered throughout the central nervous sy...
متن کاملYAP Induces Human Naive Pluripotency
The human naive pluripotent stem cell (PSC) state, corresponding to a pre-implantation stage of development, has been difficult to capture and sustain in vitro. We report that the Hippo pathway effector YAP is nuclearly localized in the inner cell mass of human blastocysts. Overexpression of YAP in human embryonic stem cells (ESCs) and induced PSCs (iPSCs) promotes the generation of naive PSCs....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: STEM CELLS
سال: 2013
ISSN: 1066-5099
DOI: 10.1002/stem.1446